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MS-275 (Entinostat)

●Purchase●DescriptionMS-275,alsoknownasEntinostat,isaninhibitorofhistonedeacetylases(HDACs)andpreferentiallyinhibitsHDAC1overHDAC3

  • 產(chǎn)品型號(hào)：27011
  • 廠商性質(zhì)：生產(chǎn)廠家
  • 更新時(shí)間：2023-11-11
  • 訪  問(wèn)  量：110
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Description

MS-275, also known as Entinostat, is an inhibitor of histone deacetylases (HDACs) and preferentially inhibits HDAC1 over HDAC3. It does not inhibit HDAC8 (IC50 > 100 µM). It induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs like adriamycin, inhibitors of PARPs, or inhibitors of Hsp90.

This product has been cited 2 times.

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Synonyms
MS-275, Entinostat
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