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NLG919

●Purchase●DescriptionNLG919isanorallyavailablepotentinhibitoroftheindoleamine-2

  • 產(chǎn)品型號(hào)：27337-2
  • 廠商性質(zhì)：生產(chǎn)廠家
  • 更新時(shí)間：2023-11-11
  • 訪  問(wèn)  量：97
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Description

NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.

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Synonyms
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, IDO inhibitor
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